Detalhe da pesquisa
1.
Identification of recurrent genomic alterations in the apoptotic machinery in chronic lymphocytic leukemia patients treated with venetoclax monotherapy.
Am J Hematol
; 97(2): E47-E51, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34779028
2.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268136
3.
Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.
Proc Natl Acad Sci U S A
; 107(28): 12634-9, 2010 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20616035
4.
CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16.
ACS Chem Biol
; 18(2): 331-339, 2023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36656921
5.
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.
ACS Chem Biol
; 17(3): 556-566, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35188729
6.
Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats.
Arch Toxicol
; 85(5): 513-23, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21046364
7.
Reducing agent-mediated precipitation of high-abundance plasma proteins.
Anal Biochem
; 387(2): 184-93, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19454248
8.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
J Pharmacol Exp Ther
; 324(2): 507-16, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18025247
9.
Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.
J Med Chem
; 61(19): 8504-8535, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29718665
10.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416490
11.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368119
12.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
13.
Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform.
J Biomol Screen
; 21(2): 201-11, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26676096
14.
Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.
J Proteome Res
; 7(11): 4807-20, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18828628